He was 61.
Macdonald had been battling cancer for several years but kept his diagnosis private, his friend and producing partner, Lori Jo Hoekstra, told CNN in a statement.
“He was most proud of his comedy. He never wanted the diagnosis to affect the way the audience or any of his loved ones saw him,” Hoekstra said. “Norm was a pure comic. He once wrote that ‘a joke should catch someone by surprise, it should never pander.’ He certainly never pandered. Norm will be missed terribly.”
Born in Quebec City, Quebec, Canada, he started in show business as a standup comedian who worked the Ottawa club circuit before branching out to clubs across Canada.
He quickly became known for his deadpan and sardonic delivery and in 1987 was given the opportunity to perform at the “Just For Laughs” Comedy Festival in Los Angeles.
That first taste of LA made an impression and Macdonald moved to the city, intent on breaking into Hollywood. He found work writing for the original “Roseanne” sitcom in 1992.
He joined the cast of “Saturday Night Live” the following year, where he became known for his impressions of David Letterman, Larry King, Burt Reynolds, Quentin Tarantino and others.
But it was as the anchor for the news sendup segment “Weekend Update” where Macdonald hit his stride.
He held the position from 1994 to 1998.
Macdonald was rather abruptly and unceremoniously dropped as the anchor of “Weekend Update,” a decision made by then-NBC West Coast president Don Ohlmeyer. Although it was reported that the executive simply didn’t like Macdonald in that role, there were reports that it had to do jokes that Macdonald had told about O.J. Simpson, who was one of Ohlmeyer’s longtime friends.
Fellow comedians Jon Stewart, Patton Oswalt, Seth Rogen and more paid tribute to Macdonald on Tuesday.